听力与言语-语言病理学

行为科学

医学伦理学

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  • Combined duodenal and colonic necrosis. An unusual sequela of caustic ingestion.

    abstract::Two unusual cases of liquid caustic ingestion that resulted in gangrene of the duodenum and adjacent colon, and burns of the esophagus, stomach, and pancreas are presented. The routine evaluation of the oropharynx, esophagus, and stomach after liquid caustic ingestion can seriously underestimate the extent of injury t...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-199412000-00009

    authors: Guth AA,Pachter HL,Albanese C,Kim U

    更新日期:1994-12-01 00:00:00

  • Steatocrit: a reliable semiquantitative method for detection of steatorrhea.

    abstract::Steatocrit is a semiquantitative method for determination of fat content in fecal samples. Previous studies, mostly performed in children, reported controversial results. The aim of our study was to compare the determination of fat content in 148 fecal samples by two methods: the conventional van de Kamer and the stea...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-199410000-00007

    authors: Sugai E,Srur G,Vazquez H,Benito F,Mauriño E,Boerr LA,Bai JC

    更新日期:1994-10-01 00:00:00

  • Upper gastrointestinal endoscopy can be a reliable screening tool for celiac sprue in adults.

    abstract::In our study, we evaluated whether the combination of two endoscopic abnormalities in the duodenum (the "mosaic" appearance and loss of duodenal folds) is significantly associated with duodenal villous atrophy secondary to celiac sprue in adults. Fourteen patients referred for esophagogastroduodenoscopy for suspected ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-199410000-00018

    authors: Magazzu G,Bottari M,Tuccari G,Arco A,Pallio S,Lucanto C,Tortora A,Barresi G

    更新日期:1994-10-01 00:00:00

  • Multiple lymphomatous polyposis of the gut.

    abstract::Multiple lymphomatous polyposis is very rare. We report two cases affecting duodenum, small intestine and colon/rectum, both with extensive disease, making radical surgery impossible and chemotherapy the treatment of choice. One patient died 23 days after initial treatment of myocardial infiltration, and the other is ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-199409000-00012

    authors: Norum J,Hovde O,Stalsberg H

    更新日期:1994-09-01 00:00:00

  • Comparison of magnetic resonance imaging and endoscopy in distinguishing the type and severity of inflammatory bowel disease.

    abstract::Twenty consecutive patients with first-time presentation of suspected inflammatory bowel disease underwent both endoscopy with biopsy and magnetic resonance imaging (MRI) within a 3-day period; the relative abilities of endoscopy and MRI to distinguish ulcerative colitis (UC) from Crohn's disease (CD) and to determine...

    journal_title:Journal of clinical gastroenterology

    pub_type: 临床试验,杂志文章

    doi:10.1097/00004836-199407000-00009

    authors: Shoenut JP,Semelka RC,Magro CM,Silverman R,Yaffe CS,Micflikier AB

    更新日期:1994-07-01 00:00:00

  • Pseudolipoma of Glisson's capsule. Report of six cases and review of the literature.

    abstract::We report six cases of pseudolipoma of Glisson's capsule. The patients ranged from 53 to 83 years old (mean 67.7 years), and all were men. Pseudolipoma of Glisson's capsule was detected by imaging studies before operation in two cases, and noted incidentally in the remaining four. Computed tomography demonstrated a su...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审

    doi:

    authors: Sasaki M,Harada K,Nakanuma Y,Watanabe K

    更新日期:1994-07-01 00:00:00

  • Body position affects recumbent postprandial reflux.

    abstract::There is a lack of consensus as to whether there is a difference in the amount of gastroesophageal reflux when lying with the right versus the left side down. In an attempt to answer this question we conducted a two-part study. The first consisted of a questionnaire distributed to 103 gastroenterologists with a specia...

    journal_title:Journal of clinical gastroenterology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00004836-199406000-00004

    authors: Katz LC,Just R,Castell DO

    更新日期:1994-06-01 00:00:00

  • Colonic findings in cirrhotics with portal hypertension. A prospective colonoscopic and histological study.

    abstract::Total colonoscopy was performed in 38 consecutive cirrhotics (15 alcoholic, 19 postviral, four unknown) with portal hypertension, 32 of whom were enrolled in a program of esophageal sclerotherapy because of variceal bleeding (Child's grading: A, 13; B, 21; C, 4 patients). In 34 of them, multiple biopsies from the colo...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-199406000-00014

    authors: Scandalis N,Archimandritis A,Kastanas K,Spiliadis C,Delis B,Manika Z

    更新日期:1994-06-01 00:00:00

  • Cytomegalovirus gastritis associated with pseudolymphoma.

    abstract::A man who previously had several episodes of upper gastrointestinal hemorrhage from erosive gastritis developed recurrent hemorrhage. Endoscopy showed punctate hemorrhages in the fundus and body of the stomach, plus a discrete area of thickened folds in the anterior wall. Biopsies revealed a dense mucosal infiltrate t...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/00004836-199404000-00011

    authors: Zucker GM,Otis C,Korowski K,Navab F

    更新日期:1994-04-01 00:00:00

  • Computerized phonoenterography: the clinical investigation of a new system.

    abstract::We assessed bowel sounds in controls and patients with acute abdominal conditions using a new computer-aided sound analysis system (C.A.S.A.S.). Sixty-three controls and 61 patients with an acute abdomen had 10-min recordings of bowel sounds in a silent environment with computer analysis of the digitized acoustic sign...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:

    authors: Sugrue M,Redfern M

    更新日期:1994-03-01 00:00:00

  • Malignancy-related ascites and ascitic fluid "humoral tests of malignancy".

    abstract::A large number of ascitic fluid tests, e.g., fibronectin and cholesterol, have been proposed as helpful in detecting malignancy as the cause of ascites. Unfortunately, these "humoral tests of malignancy" are nonspecific. Although the ascitic fluid concentrations of these proteins or protein-bound substances tend to be...

    journal_title:Journal of clinical gastroenterology

    pub_type: 社论,评审

    doi:10.1097/00004836-199403000-00002

    authors: Runyon BA

    更新日期:1994-03-01 00:00:00

  • Spectrum of ulcerative colitis in north India.

    abstract::We analyzed retrospectively the characteristics of 87 patients with ulcerative colitis seen in a tertiary care center in north India. Ulcerative colitis was diagnosed on the basis of clinical features, sigmoidoscopy, rectal biopsy, and exclusion of microbiological causes of colitis. Severe clinical disease was seen in...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-199401000-00007

    authors: Duphare H,Misra SC,Patnaik PK,Mathur M,Tandon RK

    更新日期:1994-01-01 00:00:00

  • Immunoproliferative small intestinal disease in Mexico. Report of four cases and review of the literature.

    abstract::The clinicopathologic findings in eight Mexican patients with immunoproliferative small intestinal disease (IPSID) are analyzed. Four of these cases have been previously reported and the remainder were found in a retrospective review of 42 lymphoproliferative disorders of the small bowel (9.5% of the cases at our inst...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/00004836-199401000-00016

    authors: Arista-Nasr J,González-Romo MA,Mantilla-Morales A,Lazos-Ochoa M,Ortiz-Hidalgo C

    更新日期:1994-01-01 00:00:00

  • Nasal continuous positive airway pressure. A new treatment for nocturnal gastroesophageal reflux?

    abstract::Nasal continuous positive airway pressure (CPAP) reduces nocturnal gastroesophageal reflux (GER) in obstructive sleep apnea syndrome (OSAS) patients. The primary objectives of our investigation were to determine if CPAP could reduce reflux in non-OSAS patients and, if so, by what mechanism. Esophageal pH was monitored...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-199312000-00002

    authors: Kerr P,Shoenut JP,Steens RD,Millar T,Micflikier AB,Kryger MH

    更新日期:1993-12-01 00:00:00

  • A case of cyclosporine-sensitive, steroid-resistant, autoimmune chronic active hepatitis.

    abstract::Few alternative treatments are available for those patients with autoimmune chronic active hepatitis who fail to respond to the conventional treatment of corticosteroids. Such patients have a poor prognosis and frequently require liver transplantation. We report a patient with autoimmune hepatitis who failed treatment...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-199312000-00012

    authors: Person JL,McHutchison JG,Fong TL,Redeker AG

    更新日期:1993-12-01 00:00:00

  • Is gastric metaplasia essential for duodenal ulcer?

    abstract::Multiple biopsies were taken from the duodenum of 100 patients (46 active duodenal ulcer, 14 healed duodenal ulcer, 40 control subjects) to detect duodenitis, gastric metaplasia and Helicobacter pylori (Hp). Histamine-induced congo-red staining of the duodenal bulb was performed in additional 25 cases of active duoden...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-199310000-00007

    authors: Amarapurkar DN,Parikh SS,Prabhu SR,Kalro RH,Desai HG

    更新日期:1993-10-01 00:00:00

  • Fulminant hepatic failure with massive necrosis as a result of hepatitis A infection.

    abstract::Fulminant hepatic failure as a result of hepatitis A is a rarely diagnosed complication entity in developed countries. With the advent of specific serologic markers for acute hepatitis A virus infection, the incidence and pathology of fulminant hepatitis A can be more clearly defined. We describe four patients (one ad...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-199309000-00014

    authors: Masada CT,Shaw BW Jr,Zetterman RK,Kaufman SS,Markin RS

    更新日期:1993-09-01 00:00:00

  • Brain-gut response to stress and cholinergic stimulation in irritable bowel syndrome. A preliminary study.

    abstract::To investigate the influence of the brain-gut interactions on the pathophysiology of irritable bowel syndrome (IBS), we compared such patients (n = 10) with healthy control subjects (n = 11) by measuring the pressure of the colon and small intestine simultaneously with analysis of power spectrum of the electroencephal...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-199309000-00009

    authors: Fukudo S,Nomura T,Muranaka M,Taguchi F

    更新日期:1993-09-01 00:00:00

  • Are antibiotics useful in the management of nontoxic severe ulcerative colitis?

    abstract::Severely ill patients with ulcerative colitis are usually treated with parenteral corticoids. Those with signs of systemic toxicity usually receive antibiotics as well. However, the role of antibiotics in patients without high fever, profound leukocytosis, peritoneal signs or megacolon is not clear. Since 1985, seven ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-199307000-00005

    authors: Peppercorn MA

    更新日期:1993-07-01 00:00:00

  • Effectiveness of cisapride in gastric ulcer. Results of a double-blind randomized trial versus ranitidine and versus cisapride plus ranitidine.

    abstract::Among the factors involved in the pathogenesis of gastric ulcer, the reduced clearing capacity of the stomach seems to play an important role. On this basis, cisapride, which improves gastrointestinal motility, enhances gastric emptying, and prevents duodenogastric reflux, may be effective in the treatment of the gast...

    journal_title:Journal of clinical gastroenterology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00004836-199307000-00003

    authors: Testoni PA,Bagnolo F,Buizza M,Masci E,Toti GL,Spinelli A,Manzi G

    更新日期:1993-07-01 00:00:00

  • Clarithromycin for the eradication of Helicobacter pylori.

    abstract::Helicobacter pylori infection has proven to be extraordinarily difficult to eradicate. Antimicrobial monotherapies have been particularly disappointing, with most eradication rates in the range of 0-15%. Clarithromycin has potential advantages over other macrolides to which H. pylori is susceptible because of its acid...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-199306000-00004

    authors: Graham DY,Opekun AR,Klein PD

    更新日期:1993-06-01 00:00:00

  • Enterovesical fistula due to non-Hodgkin lymphoma in AIDS.

    abstract::Enterovesical fistula associated with lymphoma is exceedingly rare. We report three patients with the acquired immunodeficiency syndrome who presented with fecaluria and pneumaturia. Non-Hodgkin lymphomas involving the intestine and the urinary bladder creating an enterovesical fistula were found at surgery in two pat...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-199306000-00015

    authors: Genta RM,Ramchandani MK,Gyorkey F,Buzanis CT,Lahart CJ

    更新日期:1993-06-01 00:00:00

  • Polymerase chain reaction in gastroenterology.

    abstract::Polymerase chain reaction (PCR) has had a major impact on molecular biology and is beginning to change our perception of certain disease processes and diagnostic tests. PCR allows the identification and amplification of very rare nucleic acid sequences. This is resulting in our identification of previously elusive inf...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/00004836-199306000-00014

    authors: Hayashi PH,Zeldis JB

    更新日期:1993-06-01 00:00:00

  • Survival after combined modality therapy for pancreatic cancer.

    abstract::Twenty consecutive patients with unresectable, locally advanced pancreatic cancer were treated with split courses of radiotherapy (RT) and simultaneous multidrug chemotherapy consisting of 5 fluorouracil, continuous infusion, streptozotocin, and cisplatin. A separate, retrospective study identified a group of 28 conte...

    journal_title:Journal of clinical gastroenterology

    pub_type: 临床试验,杂志文章

    doi:10.1097/00004836-199304000-00006

    authors: Bruckner HW,Kalnicki S,Dalton J,Snady H,Schwartz GK,Chesser MR,Lehrer D,Mandeli J,Harpaz N,Janus C

    更新日期:1993-04-01 00:00:00

  • Diagnostic workup strategies for patients with HIV-related chronic diarrhea. What is the end result?

    abstract::The intensity of diagnostic workup of patients with human immunodeficiency virus (HIV)-related chronic diarrhea is controversial. In the ideal setting in which an enteric pathogen is detected with minimal evaluation (stool tests) and in which specific treatment clears the diarrhea, eradicates the pathogen, and improve...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/00004836-199304000-00018

    authors: Rabeneck L

    更新日期:1993-04-01 00:00:00

  • Open access endoscopy: a large-scale analysis of its use in dyspeptic patients.

    abstract::We examined 2,253 consecutive dyspeptic patients referred to our endoscopy service by general practitioners ("open" group) and hospital clinicians ("clinic" group) to study the prevalence of the various endoscopic findings according to patient age and the route of endoscopic referral. The results obtained are represen...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:

    authors: Mansi C,Mela GS,Savarino V,Mele MR,Valle F,Celle G

    更新日期:1993-03-01 00:00:00

  • Celiac (solar) plexus syndrome. A frequently overlooked source of abdominal pain.

    abstract::Of the nonorganic abdominal disorders the celiac/solar plexus syndrome represents a frequently seen entity characterized by the typical association of epigastric pain and "lambda-type" tenderness. It is a special type of abdominal neurosis in which the pain arises in the periaortic nervous plexuses. Its clinical impor...

    journal_title:Journal of clinical gastroenterology

    pub_type: 社论

    doi:

    authors: Maratka Z

    更新日期:1993-03-01 00:00:00

  • Role of infectious agents in exacerbations of ulcerative colitis in India. A study of Clostridium difficile.

    abstract::Fifty patients with idiopathic ulcerative colitis--25 with acute exacerbation of the disease (Group I) and 25 in quiescent phase (Group II)--were studied. None of the patients had a history of recent exposure to antimicrobial drugs or hospitalization. Evidence of infection with protozoal and bacterial agents and/or pr...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-199301000-00008

    authors: Kochhar R,Ayyagari A,Goenka MK,Dhali GK,Aggarwal R,Mehta SK

    更新日期:1993-01-01 00:00:00

  • Helicobacter pylori and gastroduodenal disorders in India--lessons from epidemiology.

    abstract::The relationship of Helicobacter pylori and gastroduodenal disorders should be compared in the developing (DG) and developed (DD) nations (Table 1) for a better understanding of the etiopathogenesis of these disorders. Although chronic gastritis is widespread in the DG nations, benign and malignant gastric ulcer (GU) ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 社论

    doi:

    authors: Gill HH,Desai HG

    更新日期:1993-01-01 00:00:00

  • Significance of serum markers pepsinogen I and II for chronic atrophic gastritis, peptic ulcer, and gastric cancer.

    abstract::Chronic atrophic gastritis (CAG) is closely correlated with gastric cancer and is predominant in Japan. Epidemiologically, food habits are the primary factor in both CAG and gastric cancer. Two potential serum markers for CAG have recently been investigated, i.e., the concentration of serum pepsinogen (PG) and the pre...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-199312001-00026

    authors: Matsukura N,Onda M,Tokunaga A,Fujita I,Okuda T,Mizutani T,Kyono S,Yamashita K

    更新日期:1993-01-01 00:00:00

  • Age-related changes in the microvessels of the human stomach: an ultrastructural study.

    abstract::The ultrastructure of microvessels in the gastric mucosa of patients with atrophic gastritis was investigated. In the gastric mucosa of atrophic gastritis, the endothelial cells of microvessels were irregularly swollen and subendothelial spaces were enlarged. The basement membrane underlying the endothelium was thicke...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-199312001-00017

    authors: Taniguchi Y,Kimura K,Yoshida Y,Seki M,Kumakura Y,Satoh K,Kihira K,Ido K,Mato M

    更新日期:1993-01-01 00:00:00

  • Simultaneous appearance of a unique common epitope in fetal colon, skin, and biliary epithelial cells. A possible link for extracolonic manifestations in ulcerative colitis.

    abstract::The tissue distribution of a previously identified M(r) 40 K epithelial autoantigen in ulcerative colitis was examined in situ in the fetal tissue by immunocytochemical method, using an immunoglobulin M (IgM) monoclonal antibody (7E12H12). Fetal-autopsy tissue from 9 to 19 weeks of development (11-21 gestational weeks...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-199212000-00009

    authors: Das KM,Squillante L,Chitayet D,Kalousek DK

    更新日期:1992-12-01 00:00:00

  • Crohn's disease and the Jews.

    abstract::Several epidemiologic studies of Crohn's Disease (CD) from the northern hemisphere show high rates of the disease among Jews. Israel has absorbed many Jews from those countries and the rates of CD in Israel are lower than in their place of birth. Important, too, among immigrants from the middle east Mediterranean coun...

    journal_title:Journal of clinical gastroenterology

    pub_type: 社论

    doi:

    authors: Shapira M,Tamir A

    更新日期:1992-12-01 00:00:00

  • Injection sclerotherapy as a cause of Klebsiella pneumoniae peritonitis.

    abstract::We report a case of Klebsiella pneumoniae peritonitis after endoscopic sclerotherapy and discuss its pathogenesis and risk factors. We also review previous cases in the literature and make recommendations for prophylactic therapy. Endoscopists should be aware of peritonitis as a possible complication of endoscopic scl...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/00004836-199212000-00013

    authors: Trotter JF,Peterson WL

    更新日期:1992-12-01 00:00:00

  • Constipation--a sign of a disease to be treated surgically, or a symptom to be deciphered as nonverbal communication?

    abstract::Constipation is not a sign but a symptom, which is not measurable scientifically. It has emotional components and must be dealt with in a holistic manner. The scientific approach aims only at the physiological derangement and serves to place the complaint in a more objective perspective. An algorithm can be constructe...

    journal_title:Journal of clinical gastroenterology

    pub_type: 评论,社论

    doi:

    authors: Devroede G

    更新日期:1992-10-01 00:00:00

  • Acute acalculous cholecystitis. A review.

    abstract::Acute acalculous cholecystitis is an uncommon but very serious illness, that, if undiagnosed, may lead to gallbladder perforation and death. The condition has numerous causes that result in bile stasis and ischemia leading to inflammation and infection in the gallbladder wall. The bedside diagnosis may be difficult, e...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/00004836-199210000-00014

    authors: Babb RR

    更新日期:1992-10-01 00:00:00

  • Ulcerative colitis and Crohn's disease health status scales for research and clinical practice.

    abstract::We report the development of ulcerative colitis (UC) and Crohn's disease (CD) Health Status Scales that improve on existing inflammatory bowel disease (IBD) activity measures by their added association with health status. We surveyed 991 members of the Crohn's and Colitis Foundation of America (CCFA) and analyzed the ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-199209000-00005

    authors: Drossman DA,Li Z,Leserman J,Patrick DL

    更新日期:1992-09-01 00:00:00

  • Calcium and acid rebound: a reappraisal.

    abstract::We review acid rebound, the seemingly paradoxical increase in acid secretion resulting from administration of an antacid. Primarily a laboratory observation, the demonstration of the phenomenon was a major contributing factor to the swift, and possibly unjustified, fall from grace of calcium carbonate in the therapy o...

    journal_title:Journal of clinical gastroenterology

    pub_type: 临床试验,杂志文章,随机对照试验,评审

    doi:10.1097/00004836-199207000-00010

    authors: Hade JE,Spiro HM

    更新日期:1992-07-01 00:00:00

  • Chronic Pneumocystis carinii infection of the liver. A case report and review of the literature.

    abstract::Pneumocystis carinii infection of the liver is being reported with increasing frequency in patients with acquired immune deficiency syndrome (AIDS). The clinical picture typically resembles hepatitis. We report such an occurrence in a patient with persistent elevation of alkaline phosphatase and gamma-glutamyl transpe...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/00004836-199207000-00013

    authors: Merkel IS,Good CB,Nalesnik M,Roseman SR

    更新日期:1992-07-01 00:00:00

  • Right colon adenocarcinoma presenting as Bacteroides fragilis liver abscesses.

    abstract::Pyogenic abscesses of the liver occur in association with a variety of diseases. Sometimes they are caused by anaerobic infections of liver metastases. Uncommonly, however, multiple hepatic abscesses caused by anaerobic bacteria are the presenting signs of unsuspected colonic cancer in the absence of liver metastases....

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-199206000-00013

    authors: Lonardo A,Grisendi A,Pulvirenti M,Della Casa G,Melini L,Di Gregorio C,Nasi G,Sarti M,Tamborrino E,Lonardo F

    更新日期:1992-06-01 00:00:00

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